Mayo Chiki!'s main protagonist, Sakamachi Kinjirou, has the worst case of gynophobia known to man. Just one touch from a girl and his nose bleeds almost uncontrollably. His condition is all thanks to his family of female wrestlers who "trained" him a bit too much as a child. Through this tough love, Kinjirou developed a body able to withstand hard blows... as well as an intense fear of the female race. Life with such a handicap is difficult in itself, but after one ominous visit to the school restroom, Kinjirou's semi-peaceful existence shifts into complete chaos. He discovers that the suave Subaru-sama, the bodyguard to the headmaster's daughter Kanade, is actually a girl. In exchange for his silence in the matter, Kanade promises to help him overcome his gynophobia.